Our webservers and other resources

panoromics

Cancer PanorOmics

Cancer PanorOmics is a web-based resource to contextualize genomic variations detected in a personal cancer genome within the body of clinical and scientific evidence available for 26 tumor types, offering complementary cohort- and patient-centric views. Additionally, it explores the cellular environment of mutations by mapping them on the human interactome and providing quasi-atomic structural details, whenever available. You can access the server at http://panoromics.irbbarcelona.org.

 
 

dsysmap

dSysMap

dSysMap is a resource for the systematic mapping of disease-related missense mutations on the human structural interactome. It summarizes mutational data in a systemic context, and provides a unique tool to the biologist to easily grab the molecular relationships between diseases and formulate hypotheses about their mechanism of action. In addition to the precompiled data for thousands of diseases in OMIM, dSysMap allows to upload newly discovered mutations so that disease context can be readily incorporated into primary sequencing studies. You can access the server at http://dsysmap.irbbarcelona.org.

 
 

intside

IntSide

IntSide is a web server to elucidate the molecular processes involved in drug side effects through the integration of chemistry and biology. IntSide currently catalogues 1,175 side effects caused by 996 drugs, associated with drug features divided into eight categories, belonging to either biology or chemistry. On the biological side, IntSide reports drug targets and off-targets, pathways, molecular functions and biological processes. From a chemical viewpoint, it includes molecular fingerprints, scaffolds and chemical entities. Finally, we also integrate additional biological data, such as protein interactions and disease-related genes, to facilitate mechanistic interpretations. IntSide is available at http://intside.irbbarcelona.org.

 
 

interactome3d

Interactome3D

Interactome3D is a web service for the structural annotation of protein-protein interaction networks. You can submit your interactions and the server will find all the available structural data for both the single interactors and the interactions themselves. Additionally you can also visualize and download structural information for interactions involving a set of proteins or interactomes for several model organisms. You can access the server at http://interactome3d.irbbarcelona.org.

 
 

3did

3did

The database of three-dimensional interacting domains (3did) is a collection of protein interactions for which high-resolution three-dimensional structures are known. 3did exploits the a availability of structural data to provide molecular details on interactions between two globular domains as well as novel domain–peptide interactions, derived using a recently published method from our lab. The interface residues are presented for each interaction type individually, plus global domain interfaces at which one or more partners (domains or peptides) bind. The 3did web server at http://3did.irbbarcelona.org visualizes these interfaces along with atomic details of individual interactions using Jmol. The complete contents are also available for download.

NetAligner

The complex nature of biological systems requires intricate networks of protein-protein interactions that coordinate macromolecular assemblies and pathways to fulfil particular tasks in a cell. We developed NetAligner, a novel network alignment tool that allows the identification of conserved protein complexes and pathways across organisms and thus the study of how those interaction networks evolved. NetAligner is able to detect potential false positives by considering protein sequence similarities and interaction reliabilities, and addresses the issue of missing relationships through the prediction of likely conserved interactions. Gaps and mismatches in the alignment account for small amounts of network rewiring during evolution, and alignment solutions are tested for statistical significance. The web server implementation of the NetAligner algorithm features complex, pathway and interactome to interactome alignment for seven model organisms, H.sapiens, M. musculus, D.melanogaster, C. elegans, A.thaliana, S.cerevisiae and E. coli. The user can specify query complexes and pathways of arbitrary topology for alignment against a target interactome selected from our network database or choose two species interactomes to search for conserved complexes and subnetworks. Alignment solutions can be downloaded or directly visualized in the browser. The software package can be downloaded for Unix/Linux and Windows.