Towards a detailed atlas of protein-protein interactions

Mosca R, Pons T, Céol A, Valencia A, Aloy P,
Current Opinion in Structural Biology, 2013, 23(6), 929–940

Protein interaction maps are key to understand the complex world of biological processes inside the cell. Public protein databases have already catalogued hundreds of thousands of experimentally discovered interactions, and struggle to curate all the existing information dispersed through the literature. However, to be most efficient, standard protocols need to be implemented for direct submission of new interaction sets directly into databases. At the same time, great efforts are invested to expand the coverage of the interaction space and unveil the molecular details of such interactions up to the atomistic level. The net result will be the definition of a detailed atlas spanning the universe of protein interactions to guide the everyday work of the biologist.