Eduard Pauls

Research interests

I have previously worked on the identification and validation of new anti-viral or anti-inflammatory targets. Using my experience I plan to contribute to find new strategies to fight Alzheimer disease.

Previous working experience

2012 – 2014 Postdoctoral Researcher at Fundació IrsiCaixa, Badalona, Spain.

2009 – 2012 Postdoctoral Researcher at the MRC Protein Phosphorylation Unit, Dundee, Scotland, UK.

2003 – 2008 PhD Immunology at Fundació IrsiCaixa (Universitat Autònoma de Barcelona).

2000 – 2002 BSc Biochemistry. Universitat de Barcelona, Barcelona, Spain.

1996 – 2001 BSc Biology. Universitat de Barcelona, Barcelona, Spain.

Publications

Pauls E, Badia R, Torres-Torronteras J, Ruiz A, Permanyer M, Riveira-Muñoz E, Clotet B, Marti R, Ballana E, Esté JA. Palbociclib, a selective inhibitor of cyclin-dependent kinase4/6, blocks HIV-1 reverse transcription through the control of sterile α motif and HD domain-containing protein-1 activity. (2014) AIDS. [Link]

Pauls E, Ruiz A, Badia R, Permanyer M, Gubern A, Riveira-Muñoz E, Álvarez M, Mothe B, Brander C, Crespo M, Menéndez-Arias L, Clotet B, Keppler OT, Posas F, Ballana E and Esté JA. Cell cycle control and HIV-1 susceptibility are linked by a CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and lymphoid cells. (2014) J Immunol. 193(4):1988-97. [Link]

Ruiz A, Pauls E, Badia R, Riveira-Muñoz E, Clotet B, Ballana E, Esté JA. Characterization of the influence of Mediator Complex in HIV-1 Transcription. (2014) J Biol Chem. [Link]

Ballana E, Badia R, Terradas G, Torres-Torronteras J, Ruiz A, Pauls E, Riveira-Muñoz E, Clotet B, Martí R, Esté JA. SAMHD1 Specifically Affects the Antiviral Potency of Thymidine Analog HIV Reverse Transcriptase Inhibitors. (2014) Antimicrob Agents Chemother. 58(8):4804-13. [Link]

Badia R, Pauls E, Riveira-Munoz E, Clotet B, Esté JA, Ballana E. Zinc Finger Endonuclease Targeting PSIP1 Inhibits HIV-1 Integration. (2014) Antimicrob Agents Chemother. 58(8):4318-27. [Link]

Tan L, Nomanbhoy T, Gurbani D, Patricelli M, Hunter J, Geng J, Herhaus L, Zhang J, Pauls E, Ham Y, Choi HG, Xie T, Deng X, Buhrlage SJ, Sim T, Cohen P, Sapkota G, Westover KD, Gray NS. Discovery of Type II Inhibitors of TGFβ-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2). (2014) J Med Chem. [Link]

Riveira-Muñoz E, Ruiz A, Pauls E, Permanyer M, Badia R, Mothe B, Crespo M, Clotet B, Brander C, Ballana E, Esté JA. Increased expression of SAMHD1 in a subset of HIV-1 elite controllers. (2014) J Antimicrob Chemother. [Link]

Pauls E, Ruiz A, Riveira-Muñoz E, Permanyer M, Badia R, Clotet B, Keppler OT, Ballana E and Esté JA. p21 regulates the HIV-1 restriction factor SAMHD1. (2014) PNAS. 111(14):E1322-4.[Link]

Permanyer M, Pauls E, Badia R, Esté JA, Ballana E. The cortical actin determines different susceptibility of naïve and memory CD4+ T cells to HIV-1 cell-to-cell transmission and infection. (2013) PLoS One. 8(11):e79221. [Link]

Pauls E, Nanda SK, Smith H, Toth R, Arthur JSC and Cohen P. Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice. (2013) J Immunol. 191(5):2717-30. [Link]

Pauls E, Jimenez E, Ruiz A, Permanyer M, Ballana E, Costa H, Nascimiento R, Parkhouse RM, Peña R, Riveiro-Muñoz E, Martinez MA, Clotet B, Esté JA, Bofill M. Restriction of HIV-1 replication in primary macrophages by IL-12 and IL-18 through the upregulation of SAMHD1. (2013) J Immunol. 190(9):4736-41. [Link]

Pauls E, Ballana E, Esté JA. Nucleotide embargo by SAMHD1: a strategy to block retroviral infection. (2013) Antiviral Res. 97(2):180-2. [Link]

Permanyer M, Ballana E, Badia R, Pauls E, Clotet B, Esté JA. Trans-infection but not infection from within endosomal compartments after cell-to-cell HIV-1 transfer to CD4+ T cells. (2012) J Biol Chem. 287(38):32017-26. [Link]

Pauls E, Shpiro N, Peggie M, Young ER, Sorcek RJ, Tan L, Choi HG, Cohen P. Essential role for IKKβ in production of type 1 interferons by plasmacytoid dendritic cells. (2012) J Biol Chem. 287(23):19216-28.[Link]

Ballana E, Pauls E, Clotet B, Perron-Sierra F, Tucker GC, Esté JA. β5 integrin is the major contributor to the αVintegrin-mediated blockade of HIV-1 replication. (2011) J Immunol. 186(1):464-70. [Link]

Ballana E, Senserrich J, Pauls E, Faner R, Mercader JM, Uyttebroeck F, Palou E, Mena MP, Grau E, Clotet B, Ruiz L, Telenti A, Ciuffi A, Esté JA. ZNRD1 (zinc ribbon domain-containing 1) is a host cellular factor that influences HIV-1 replication and disease progression. (2010) Clin Infect Dis. 50(7):1022-32.[Link]

Pauls E, Ballana E, Moncunill G, Bofill M, Clotet B, Ramo-Tello C, Esté JA. Evaluation of the anti-HIV activity of natalizumab, an antibody against integrin alpha4. (2009) AIDS. 23(2):266-8. [Link]

Ballana E, Pauls E, Senserrich J, Clotet B, Perron-Sierra F, Tucker GC, Esté JA. Cell adhesion through alphaV-containing integrins is required for efficient HIV-1 infection in macrophages. (2009) Blood. 113(6):1278-86. [Link]

Moncunill G, Armand-Ugón M, Clotet-Codina I, Pauls E, Ballana E, Llano A, Romagnoli B, Vrijbloed JW, Gombert FO, Clotet B, De Marco S, Esté JA. Anti-HIV activity and resistance profile of the CXC chemokine receptor 4 antagonist POL3026. (2008) Mol Pharmacol. 73(4):1264-73. [Link]

Moncunill G, Armand-Ugón M, Pauls E, Clotet B, Esté JA. HIV-1 escape to CCR5 coreceptor antagonism through selection of CXCR4-using variants in vitro. (2008) AIDS. 22(1):23-31. [Link]

Senserrich J, Pauls E, Armand-Ugón M, Clotet-Codina I, Moncunill G, Clotet B, Esté JA. HIV-1 resistance to the anti-HIV activity of a shRNA targeting a dual-coding region. (2008) Virology. 372(2):421-9. [Link]

Pauls E, Senserrich J, Bofill M, Clotet B, Esté JA. Induction of interleukins IL-6 and IL-8 by siRNA. (2007) Clin Exp Immunol. 147(1):189-96. [Link]

Pauls E, Senserrich J, Clotet B, Esté JA. Inhibition of HIV-1 replication by RNA interference of p53 expression. (2006) J Leukoc Biol. 80(3):659-67. [Link]

Bosch B, Clotet-Codina I, Blanco J, Pauls E, Coma G, Cedeño S, Mitjans F, Llano A, Bofill M, Clotet B, Piulats J, Esté JA. Inhibition of human immunodeficiency virus type 1 infection in macrophages by an alpha-v integrin blocking antibody. (2006) Antiviral Res. 69(3):173-80. [Link]

Bosch B, Blanco J, Pauls E, Clotet-Codina I, Armand-Ugón M, Grigorov B, Muriaux D, Clotet B, Darlix JL, Esté JA. Inhibition of coreceptor-independent cell-to-cell human immunodeficiency virus type 1 transmission by a CD4-immunoglobulin G2 fusion protein. (2005) Antimicrob Agents Chemother. 49(10):4296-304. [Link]

Pauls E and Esté JA. RNA interference as a tool for target validation. (2004) Drug Discovery Today Technologies 1(2):135-140. [Link]