Richa Mudgal

Post-doctoral Fellow

Structural Bioinformatics and Network Biology group
Institute for Research in Biomedicine (IRB)
Parc Científic de Barcelona
C/ Baldiri Reixac 10
08028 Barcelona - Spain

richa.mudgal <at>

Research interests

Computational biology of proteins: structure, function and evolution. Structural-system biology and biological network analysis

Previous working experience

2008 - 2015 PhD in Computational Biology from IISc. Mathematics Initiative, Indian Institute of Science, Bangalore India

2007 - 2008 Project Assistant at National Institute of Immunology, New Delhi, India

2007 Six months dissertation project National Institute of Immunology, New Delhi, India

2006 Six months summer project at Institute of Genomics and Integrative Biology, New Delhi, India


Becker JR, Pons C, Nguyen HD, Costanzo M, Boone C, Myers CL, Bielinsky AK. 5’ Flap-dependent activation of postreplicative repair MacNeil LT, Pons C, Arda HE, Giese GE, Myers CL, Walhout AJM. A gene-centered in vivo regulatory network reveals complex transcription factor hierarchies

Sandhya S., Mudgal R., Kumar G., Sowdhamini R. and Srinivasan N. (2016) Protein sequence design and its applications. Curr. Opin. Struct. Biol., 37, 71-80

Mudgal R., Sandhya S., Chandra N. and Srinivasan N. (2015) De-DUFing the DUFs: Deciphering distant evolutionary relationships of DUFs using sensitive homology detection methods. Biology Direct, 10:38.

Srinivasan N., Mudgal R., Kumar G., Chandra N.R., Sowdhamini R. and Sandhya S. (2015) 161 Bridging the islands of protein families in sequence space using artificial sequences. J. Biomol. Struct. Dyn., 33 Suppl 1:103-4.

Ramakrishnan G., Ochoa-Montaño B., Upadhyayula R.S., Mudgal R., Joshi A.G., Chandra N.R., Sowdhamini R., Blundell T.L. and Srinivasan N. (2014) Enriching the annotation of Mycobacterium tuberculosis H37Rv proteome using remote homology detection approaches: Insights into structure and function. Tuberculosis, Vol. 5 (1): 14-25

Mudgal R., Sandhya S., Kumar G., Sowdhamini R., Chandra N. and Srinivasan N. (2014) NrichD database: sequence databases enriched with computationally designed protein-like sequences aid in remote homology detection. Nuc. Acids Res., Vol. 43 (Database issue): D300-305.

Mudgal R., Sowdhamini R., Chandra N., Srinivasan N. and Sandhya S. (2014) Filling-in void and sparse regions in protein sequence space by protein-like artificial sequences enables remarkable enhancement in remote homology detection capability. J. Mol. Bio., Vol. 426(4): 962-979.

Chandra S., Priyadarshini R., Madhavan V., Tikoo S., Hussain M., Mudgal R., Modi P., Srivastava V. and Sengupta S. (2013) Enhancement of c-Myc degradation by Bloom (BLM) helicase leads to delayed tumor initiation. J. Cell Sci., Vol. 126: 3782-3795.

Sandhya S., Mudgal R., Jayadev C., Abhinandan K.R., Sowdhamini R. and Srinivasan N. (2012) Cascaded walks in protein sequence space: use of artificial sequences in remote homology detection between natural proteins. Mol. BioSys., Vol. 8: 2076–2084

Ramakrishnan G., Gowri V.S., Mudgal R., Chandra N.R. and Srinivasan N. (2012) Mining the sequence databases for homology detection: Application to recognition of functions of Trypanosoma brucei brucei proteins and drug targets. Biological Data Mining and Its Applications in Healthcare (Book Chapter).

De S., Kumari J., Mudgal R., Modi P., Gupta S., Futami K., Goto H., Lindor N.M., Furuichi Y., Mohanty D. and Sengupta S. (2012) RECQL4 is essential for the transport of p53 to mitochondria in normal human cells in the absence of exogenous stress. J. Cell Sci., Vol. 125: 2509–2522.

Srinivasan N., Agarwal G., Bhaskara R.M., Gadkari R., Krishnadev O., Lakshmi B., Mahajan S., Mohanty S., Mudgal R., Rakshambikai R., Sandhya S., Sudha G., Swapna L.S. and Tyagi N. (2010) Influence of genomic and other biological data sets in the understanding of protein structures, functions and interactions. Int. J. Knowledge Discovery Bioinf. Vol. 2(1): 24-44.

Kaur S., Modi P., Srivastava V., Mudgal R., Tikoo S., Arora P., Mohanty D. and Sengupta S. (2010) Chk1-dependent constitutive phosphorylation of BLM helicase at Serine 646 decreases after DNA damage. Mol. Cancer Res., Vol. 8: 1234-1247

Srivastava S., Modi P., Tripathi V., Mudgal R., De S. and Sengupta S. (2009) BLM helicase stimulates the ATPase and chromatin remodeling activities of RAD54. J. Cell Sci., Vol 122: 3093-3103.

Database updates and online publications

Mudgal R., Krishnadev O., Mukherjee S. and Srinivasan N. (2010, 2011, 2012, 2013) SUPFAM,

Mohanty S., Mudgal R., Krishnadev O. and Srinivasan N. (2010) MulPSSM,